The Bone-Inflammation-Cartilage (BIC) Stain

The cartilage-bone interface.

In the knee joint, the purpose of the cartilage-bone interface is to maintain structural integrity of the osteochondral unit during walking, kneeling, pivoting, and jumping--during which tensile, compressive, and shear forces are transmitted from the viscoelastic articular cartilage layer to the much stiffer mineralized end of the long bone. Mature articular cartilage is integrated with subchon...

Bone and Cartilage Healing

Bone and cartilage healing are central to the practice of orthopedic surgery. Orthopaedic treatments should attempt to optimize the cells, scaffold, molecules, and blood supply required for healing. This chapter will describe the components required for successful healing, detail the role of each factor, and outline the complex interactions that occur during the healing processes of bone and ca...

Geometric BIC

The author introduced the “geometric AIC” and the “geometric MDL” as model selection criteria for geometric fitting problems. These correspond to Akaike’s “AIC” and Rissanen’s “BIC”, respectively, well known in the statistical estimation framework. Another criterion well known is Schwarz’ “BIC”, but its counterpart for geometric fitting has been unknown. This paper introduces the corresponding ...

Bone – Inflammation

Figure Legend: Figure 1 Bone Inflammation, Chronic in the bone of a male F344/N rat from a chronic study. Bone resorption is associated with inflammation. Figure 2 Bone Inflammation, Chronic in a male B6C3F1/N mouse from a chronic study. Inflammatory cells surround a piece of bone that is undergoing resorption (sequestrum). Figure 3 Bone Inflammation, Chronic in a male F344/N rat from a chronic...

Interactions between subchondral bone and cartilage in OA. Cells from osteoarthritic bone can alter cartilage metabolism.